The global adoption of cryptocurrencies is experiencing a significant surge. Despite the diverse economic challenges in the Mediterranean region, some countries are increasingly embracing alternative currencies due to various economic and social factors. This study aims to investigate the determinants of cryptocurrency adoption in Mediterranean countries. Given the complexity of this phenomenon, our analysis extends beyond individual nations to encompass regional dynamics. Our findings suggest that cryptocurrency adoption is higher in countries characterized by a limited number of bank branches, a lower proportion of young people, and reduced internet access. These insights contribute to a deeper understanding of the unique economic and social drivers behind the rise of cryptocurrencies in this region.